Recently, the Nobel Prize in chemistry, 2022 was awarded to scientists Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for their development of ‘click chemistry’ and ‘bioorthogonal chemistry’.
So let us assess their applications of ‘Click chemistry’ and understand how it works.
Fluorophores are microscopic molecules, which may be proteins, small organic compounds, or synthetic polymers that absorb light of specific wavelengths and emit light of longer wavelengths. |
Bio-orthogonal Chemistry:
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What are its applications?
How it works?
Is Click Chemistry irreversible?
Additional applications include:
Limitations:
Limitations emerge from the chemistry of the probe to its target. In order for this technique to be useful in biological systems, click chemistry must run at or near biological conditions, produce little and (ideally) non-toxic byproducts, have (preferably) single and stable products at the same conditions, and proceed quickly to high yield in one pot.
Verifying, please be patient.
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