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11th February 2025 (12 Topics)

Biolumpivaxin Vaccine

Context

Bharat Biotech’s group company, Biovet, has received approval from the Central Drugs Standard Control Organisation (CDSCO) to market a vaccine against Lumpy Skin Disease (LSD) in dairy cattle and buffaloes. This vaccine, named Biolumpivaxin is the world’s first Differentiating Infected from Vaccinated Animals (DIVA) marker vaccine for LSD.

About the Vaccine (Biolumpivaxin):

  • Biolumpivaxin is a live-attenuated marker vaccine developed by Biovet in collaboration with the Indian Council of Agricultural Research-National Research Centre on Equines (ICAR-NRCE).
  • The vaccine uses the LSD virus/Ranchi/2019 strain and provides single-dose vaccination for cattle and buffaloes above 3 months of age.
  • It is the world’s only DIVA marker vaccine, allowing the distinction between vaccinated and naturally infected animals.
  • Storage and Efficacy: The vaccine is stable at a temperature range of 2-80°C and has shown high safety and efficacy.
  • Production Capacity: Biovet can produce up to 500 million doses of the vaccine, which will be commercially available soon.
  • Significance: This vaccine marks a crucial step toward India's self-reliance in veterinary healthcare, supporting the Atmanirbhar Bharat initiative and reducing dependency on imported vaccines.

About:

Lumpy Skin Disease (LSD):

  • Lumpy skin disease is caused by the lumpy skin disease virus (LSDV), which belongs to the genus capripox virus, a part of the poxviridae family (smallpox and monkeypox viruses are also a part of the same family).
  • The LSDV shares antigenic similarities with the sheeppox virus (SPPV) and the goatpox virus (GTPV) or is similar in the immune response to those viruses.
  • It is not a zoonotic virus, meaning the disease cannot spread to humans.
  • It is a contagious vector-borne disease spread by vectors like mosquitoes, some biting flies, and ticks and usually affects host animals like cows and water buffaloes. 
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