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Hypertension (High Blood Pressure)
Context
The study TOPSPIN (Treatment Optimization for Blood Pressure with Single-Pill Combinations in India), conducted over two years with collaboration between All India Institute of Medical Sciences (AIIMS), Delhi and Imperial College, London, aimed at finding an effective and easy way to manage high blood pressure (hypertension) in India.
Key Findings of the Study:
- The study looked at the effectiveness of combining two blood pressure (BP) drugs into a single pill that can be taken once a day. This is a simpler approach for people who need different BP medications at different times of the day.
- It found that two-drug combinations of three widely used medicines used in patients with high blood pressure (BP) are far more effective in controlling the condition than single medicines.
- The TOPSPIN Study evaluated three two-drug combinations—
- Amlodipine + Perindopril
- Amlodipine + Indapamide
- Perindopril + Indapamide
- All three combinations were equally effective at reducing BP. After six months, the average reduction in BP was around 14/8 mmHg for ambulatory BP (measured throughout the day) and 30/14 mmHg for office BP (taken at the doctor's office).
- 70% of participants achieved BP levels below 140/90 mmHg, which is the target for BP control. This was a fivefold improvement compared to the current BP control rates in India.
- Safety: The study found excellent safety for all drug combinations, with less than 3% of participants discontinuing the drugs due to side effects.
- The combination pills have fewer side effects compared to taking two separate medicines at full doses.
Why is this Important?
- This is the first randomized study to test the best drug combinations for controlling BP specifically in Indians and South Asians, a group that makes up about 25% of the world’s population.
- India has over 300 million people suffering from hypertension, and currently, less than 15% of hypertensive patients in India manage to control their BP effectively.
- This study shows that using combination pills once a day could significantly improve BP control and is a practical approach to managing hypertension in India.
Fact Box:High Blood Pressure
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