Published: 29th Jun, 2020
A team of researchers at the Department of Biotechnology’s National Centre for Cell Science (DBT-NCCS) in Pune has been exploring ways to tackle miltefosine resistance.
- A team of researchers at the Department of Biotechnology’s National Centre for Cell Science (DBT-NCCS) in Pune has been exploring ways to tackle miltefosine resistance.
- The researchers worked with one of the species of Leishmania that causes infection, called Leishmania major.
- The only drug available against leishmaniasis, miltefosine, is rapidly losing its effectiveness because of emerging resistance to this drug due to a decrease in its accumulation inside the parasite, which is necessary for the drug to kill the parasite.
What is Kala- azar?
- TLeishmaniasis, which is commonly known as Kala-azar in India, is a neglected tropical disease affecting almost 100 countries including India.
- It is caused by a parasite called Leishmania, which is transmitted through the bite of sand flies.
- There are three main forms of leishmaniasis:
- visceral, which affects multiple organs and is the most serious form of the disease
- cutaneous, which causes skin sores and is the most common form
- mucocutaneous, which causes skin and mucosal lesion.
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