7th April 2025 (16 Topics)

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Semaglutide

Context

A recent global phase 3 trial (SOUL trial) showed that oral semaglutide — a drug for type 2 diabetes — reduced the risk of heart attacks, strokes, and cardiovascular deaths by 14%, highlighting the need for cardio-renal protection in diabetes management.

What is Semaglutide?

Semaglutide is a GLP-1 receptor agonist (GLP-1RA) used to:
- Treat type 2 diabetes
- Manage long-term weight loss in people with obesity or related conditions
It was approved in India in June 2021 for weight management alongside diet and exercise.
Semaglutide addresses both diabetes and cardiovascular risk — tackling India’s dual burden of diabetes and CVD.

Fact Box: About Diabetes

Diabetes mellitus, also known as diabetes, is a metabolic disease marked by consistently elevated blood sugar levels.
Diabetes is a chronic illness in which the body either produces insufficient amounts of insulin or is unable to use the insulin that it does produce efficiently.
The pancreas secretes the hormone insulin, which is crucial for controlling blood sugar levels. Blood sugar levels can rise and cause issues with the heart, kidneys, feet, and eyes if insulin is not functioning properly.
Types:
Type 1 diabetes: This type of diabetes is also called insulin-dependent diabetes. People with Type 1 diabetes must take insulin and also may take other medications daily. This makes up for the insulin not being produced by the body.
Type 2 diabetes: Type 2 diabetes is the most common form of diabetes. Type 2 diabetes has historically been diagnosed primarily in adults. But adolescents and young adults are developing Type 2 diabetes at an alarming rate because of family history and higher rates of obesity and physical inactivity.

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Semaglutide

What is Semaglutide?

Fact Box: About Diabetes

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