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Hyderabad’s Biological E to get mRNA technology from WHO to produce Covid vaccines

  • Published
    5th Apr, 2022
Context

Hyderabad-based vaccine manufacturer Biological E. Limited (BE) recently announced that it had been selected as a recipient of mRNA technology from the World Health Organisation (WHO) technology transfer hub.

About

About mRNA vaccines:

  • The first known demonstration of RNA vaccines was by scientists at Karolinska Institute in
  • The earliest known attempt to use mRNA against disease is attributed to Hungarian biochemist Katalin Kariko.
  • mRNA vaccines trick the body into producing some of the viral proteins itself.
  • They work by using mRNA, or messenger RNA, which is the molecule that essentially puts DNA instructions into action.
  • Inside a cell, mRNA is used as a template to build a protein.

How it works?

  • To produce an mRNA vaccine, scientists produce a synthetic version of the mRNA that a virus uses to build its infectious proteins.
  • This mRNA is delivered into the human body, whose cells read it as instructions to build that viral protein, and therefore create some of the virus’s molecules themselves.
  • These proteins are solitary, so they do not assemble to form a virus.
  • The immune system then detects these viral proteins and starts to produce a defensive response to them.

World Health Organisation

  • The WHO was established on 7 April 1948, which is commemorated as World Health Day.
  • It is headquartered in Geneva, Switzerland, with six semi-autonomous regional offices and 150 field offices worldwide.
  • The first meeting of the World Health Assembly (WHA), the agency’s governing body, took place on 24 July 1948.
    • The WHA, composed of representatives from all 194 member states, serves as the agency’s supreme decision-making body.
    • The WHA convenes annually and is responsible for selecting the Director-General, setting goals and priorities, and approving the WHO’s budget and activities.
  • The WHO is a specialised agency of the United Nations responsible for international public health.
  • It is part of the U.N. Sustainable Development Group.
  • The WHO Constitution, which establishes the agency’s governing structure and principles, states its main objective as ensuring “the attainment by all peoples of the highest possible level of health.”
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