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27th June 2022 (6 Topics)

Typhoid: S. Typhi is more drug-resistant


According to a study, the bacteria causing typhoid fever is becoming increasingly resistant to some of the most important antibiotics for human health.


Key findings of the study:

  • The largest genome analysis of Salmonella Typhi (S. Typhi) shows that resistant strains, almost all originating in South Asia have spread to other countries nearly 200 times since 1990.
  • The researchers noted that typhoid fever is a global public health concern, causing 11 million infections and more than 1,00,000 deaths per year.
  • It is most prevalent in South Asia, which accounts for 70% of the global disease burden.
  • It also has significant impacts in sub-Saharan Africa, Southeast Asia, and Oceania, highlighting the need for a global response.
  • Antibiotics can be used to successfully treat typhoid fever infections, but their effectiveness is threatened by the emergence of resistant S. Typhi strains.

About Typhoid fever:

  • Typhoid fever is caused by Salmonella typhi bacteria.
  • Typhoid fever is rare in developed countries.
  • It is still a serious health threat in the developing world, especially for children.
  • Contaminated food and water or close contact with an infected person cause typhoid fever.
  • Signs and symptoms usually include:
  • High fever
  • Headache
  • Stomach pain
  • Constipation or diarrhea
  • Causes
  • Typhoid fever is caused by dangerous bacteria called Salmonella typhi.
  • Salmonella typhi is a multiorgan pathogen characterized to inhabit the lymphatic tissues of the small intestine, liver, spleen, and bloodstream of infected humans.

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