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CDO-7N-1, needle-free Covid-19 vaccine
Context
Hyderabad-based vaccine maker Indian Immunologicals Limited (IIL) has developed a live-attenuated needle-free intra-nasal booster vaccine against Sars-CoV-2 virus that causes Covid-19, amid the rising number of cases of the virulent across the world.
About the vaccine
- Needle-free injection systems are novel ways to introduce various medicines into patients without piercing the skin with a conventional needle.
- IIL’s intranasal vaccine, named CDO-7N-1, is a live attenuated vaccine designed to be given through the nose. It could trigger both mucosal and systemic immunity with just a single dose
- The vaccine is made using codon deoptimisation technology.
- Codon deoptimization involves decreasing the frequency of underrepresented codon pairs (genetic determinant for amino acids) without changing amino acid sequences.
- It is a highly efficient virus attenuation strategy that utilizes suboptimal codon pairs to achieve attenuation of recoded viruses
- The technology weakens viruses by using less common genetic codes while keeping the protein the same.
- Codon deoptimisation is considered highly efficient as a virus attenuation strategy and is also considered safe and less time-consuming than the conventional way which usually takes several years.
- Live-attenuated vaccines are known for their ability to induce strong, long-lasting immunity, often requiring just one dose.
- Unlike other vaccines that use a single antigen, live-attenuated vaccines incorporate the entire virus, providing broader immunity.
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