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03rd January 2025 (12 Topics)

Cervical Cancer

Context

January is Cervical Cancer Awareness Month. It is a perfect opportunity for WHO and partners to raise awareness about cervical cancer and HPV vaccination.

What is Cervical Cancer?

  • Cervical cancer is a type of cancer that occurs in the cells of the cervix- the lower part of the uterus that connects to the vagina.
  • Caused by: The primary cause is the Human Papillomavirus (HPV), a dangerous virus. The majority of cases of cervical cancer (99%) are associated with HPV infection.
    • Other risk factors: Multiple sexual partners, starting the journey into sexual activity at a young age heightens vulnerability, infections like chlamydia, gonorrhea, syphilis, and HIV/AIDScan increase the risk, and smoking can also elevated risk of cervical cancer.
  • Symptoms:Although most infections with HPV resolve spontaneously and cause no symptoms, persistent infection can cause cervical cancer in women.
  • Prevention: Effective primary (HPV vaccination) and secondary prevention approaches(screening for, and treating precancerous lesions) will prevent most cervical cancer cases.
  • Cervical Cancer Types
  • Squamous cell carcinoma: This forms in the lining of your cervix. It’s found in up to 90% of cases.
  • Adenocarcinoma: This forms in the cells that produce mucus.
  • Mixed carcinoma: This has features of the two other types.

HPV

  • HPV is an extremely common virus transmitted through sexual contact.
  • It is complicated by the fact that it can last for years, causing changes in cervical cells over time and ultimately opening the door for cancer.
  • HPV Vaccine: The HPV vaccine can prevent most cases of cervical cancer if the vaccine is given before girls or women are exposed to the virus.
    • Quadrivalent vaccine (Gardasil): It protects against four types of HPV (HPV 16, 18, 6 and 11). The latter two strains cause genital warts.
    • Bivalent vaccine (Cervarix): It protects against HPV 16 and 18 only.
    • Non-valent vaccine (Gardasil 9): It protects against nine strains of HPV.

India-made vaccine

Cervavac (quadrivalent): This is India's first indigenous HPV vaccine, launched in January 2023, It has been developed and manufactured by Pune-based Serum Institute of India (SII). It targets the same four HPV types as Gardasil.

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