A group of researchers from CSIR-Centre for Cellular and Molecular Biology, Hyderabad (CCMB) and Tata Institute for Genetics and Society, Bengaluru (TIGS), have established a way of studying the nuclear matrix of the fruit fly (Drosophila melanogaster) without removing the nucleus from the embryo.
Every cell that makes up an organism contains a copy of its genome.
This genome is packaged in special ways with the help of a structure known as the nuclear matrix.
The nuclear matrix gives an organisation and architecture to the nucleus.
The nuclear matrix is scaffolding that helps package the genome differently in different types of cells.
Similar to cytoskeleton, the nuclear matrix largely provides mechanical support.
It includes the nuclear lamina, which is the dense fibrous network juxtaposes the nuclear envelope and continuous outside to the endoplasmic reticulum.
There are two major components of the nuclear lamina:
intermediate filaments, particularly lamins and
nuclear lamin-associated membrane proteins
The nuclear matrix is suggested to generally have the following components:
the residual elements of the nuclear envelope, i.e. the pore complex-lamina,
the residual nucleoli, and
a granular and fibrous matrix structure extending throughout the nucleus